Vilon Peptide: Potential Research Applications

Scientists interested in neuroprotective peptides are devoting more and more time to studying the Vilon compound. Research studies have hypothesized the possible functions of the synthetic dipeptide Vilon in:

  • Anti-cell aging potential 
  • Regeneration of organs and tissues 
  • Immune system operations 

This guide, written by our peptide review team, describes the peptide’s possible properties and potential effects, together with a Vilon review. The team also covers the relevant studies to date. Please keep reading to find out the best vendor for research chemicals, selling high-purity Vilon to accredited labs worldwide. 

Vilon Peptide: What is it?

Studies suggest that Vilon is a dipeptide with possible bioregulatory, anti-aging, and immunomodulatory properties; it is sometimes called lysylglutamic acid or Lys-Glu. Russian researchers have indicated the metabolic activity and geroprotective impact of the peptide Vilon, and they have focused mostly on cell aging and cancer formation. 

Vilon is reported to stimulate interleukin-2 signaling in spleen cells and to function via activating heterochromatin. In addition to its important antioxidant and anti-stress characteristics, it has been hypothesized to speed wound healing, activate cells in connective tissue, and promote tissue regeneration.

Since the thymus gland is an essential part of the immune system, research has suggested that Vilon may sustain and replenish it, making it a powerful geroprotector. This organ has been theorized to regulate the development and synthesis of immune cells, or lymphocytes, which protect the organism from external threats and illnesses and slow cell aging. 

The thymus’s function decreases as it progressively atrophies after reaching its peak during its young years. Vilon has been speculated to aid the immune system and slow cell aging by stimulating the thymus gland.

Vilon Properties Research 

According to the published study, Vilon seems to protect the heart and kidneys, boost immunological function, and decrease physiological decline and related issues. 

Vilon Peptide and Longevity

As suggested by many studies, Vilon may slow the onset of age-related diseases. The following is an overview of Vilon’s work in the fields of anti-cell aging and longevity research: 

  • Earlier research on rodents suggested that young mice appeared to live longer after receiving a five-day course of thymus-produced polypeptide factor once a month, reducing the overall incidence of tumors and mammary adenocarcinoma. 
  • In another investigation on young mice, Vilon seemed to have increased physical activity and endurance, decreased internal temperature, prevented spontaneous neoplasms, and prolonged cell longevity. 
  • Vilon is hypothesized to promote cell longevity by increasing glucose buildup and preserving nutritional extraction in older mice by improving enzyme function in their gastrointestinal tracts. 
  •  Research indicated that Vilon may promote cell proliferation and repair neurons in the brain and ocular retinas. 
  •  Data suggests that Vilon may delay skin cell aging by reversing the age-related decline in collagen type 1 and sirtuin 6 expression. After subjecting aged skin fibroblasts to Vilon, scientists theorized an 83% increase in collagen type 1 expression area and a twofold increase in sirtuin 6 expression area in the cultured cells. 

Vilon Peptide and the Immune System

Vilon has been hypothesized to be an effective immune system regulator that may help the organism fight infections by activating white blood cells and other systems. The following studies address the possibility that Vilon may improve immunological function, particularly in aged animal research models: 

  • Vilon was speculated to enhance cellular healing and boost the innate immune system. This is believed to have led to improvement in 56 research models with damaged limb osteomyelitis following a necro sequestrectomy, and the research models’ time under observation was reduced. 
  • By deciphering heterochromatin, Vilon has been asserted to help activate certain genes. Chromatin fibers regulate DNA replication, transcription, genetic recombination, and cell division, which restores immune function in aged animal research models. 
  • In addition to possibly controlling the immune response to microbial infections and helping to avoid autoimmune responses, Vilon is theorized to increase interleukin-2 signaling in spleen cells. 
  • Vilon is believed to be a key component in developing T cells, namely cytotoxic CD8 T cells and CD5 T cells, and it has been indicated to activate the thymus gland. These cells aid antimicrobial response, immunological function, and autoimmune disease prevention. 
  • As further speculation of its geroprotective potential, Vilon has been implied to control the production of CD4, CD5, and CD8 glycoproteins in thymic cell cultures and drive the differentiation of immune cells. 

 Vilon Peptide and Arteries 

Vilon’s importance in vascular function is being explored increasingly, along with its potential impact on immunological function and lifespan. In renal failure, researchers have speculated that Vilon may reduce transforming growth factor-beta concentrations, leading to microvessel permeability and improved homeostasis. 

Increased levels of the natural anticoagulants antithrombin 3 and protein c are believed to be another consequence of Vilon’s potential on gene expression patterns in the cardiovascular system. Additionally, it has been speculated to promote fibrinolysis in aged animal research models of diabetes, leading to a decrease in blood clot occurrence and improved regulation of the vascular system. 


The peptide’s possibly practical effects on lifespan, immunological function, and cardiovascular function are only a few Vilon properties supported by substantial studies.

Researchers interested in peptides for sale online may visit the Core Peptides website for the highest-quality research compounds.


[i] Khavinson, V.K., Kuznik, B.I. & Ryzhak, G.A. Peptide bioregulators: A new class of geroprotectors, report 2. The results of clinical trials. Adv Gerontol 4, 346– 361 (2014).

[ii] Kozina, Ljudmila & Kochkina, E. & Nalivaeva, Natalia & Beliaev, Nikolai & Turner, A. & Arutjunyan, Alexander. (2008). The effects of vilon and epithalon peptides on the expression of neprilysin and insulin[1]degrading enzyme in human neuroblastoma NB7 cells under normal and hypoxic conditions. Neurochemical Journal. 2. 69-71. 10.1134/S1819712408010133.

[iii] Khavinson, V.K. Tissue-Specific Effects of Peptides. Bulletin of Experimental Biology and Medicine 132, 807–808 (2001).

[iv] Nina Kolchina, Vladimir Khavinson, Natalia Linkova, Alexander Yakimov, Dmitry Baitin, Arina Afanasyeva, Michael Petukhov, Systematic search for structural motifs of peptide binding to double-stranded DNA, Nucleic Acids Research, Volume 47, Issue 20, 18 November 2019, Pages 10553–10563,

[v] Morozov, V. G., & Khavinson, V. K. (1998, August 5). Natural and synthetic thymic peptides as therapeutics for immune dysfunction. International Journal of Immunopharmacology. Retrieved August 4, 2022, from i/S0192056197000581

[vi] Anisimov VN, Loktionov AS, Khavinson VK, Morozov VG. Effect of low-molecular-weight factors of thymus and pineal gland on life span and spontaneous tumour development in female mice of different age. Mech Ageing Dev. 1989;49(3):245-257. doi:10.1016/0047-6374(89)90075-4

[vii] Khavinson VK, Anisimov VN, Zavarzina NY, Zabezhinskii MA, Zimina OA, Popovich IG, Shtylik AV, Malinin VV, Morozov VG. Effect of Vilon on biological age and lifespan in mice. Bull Exp Biol Med. 2000 Jul;130(7):687-90. doi: 10.1007/BF02682106. PMID: 11140587.

[viii] Khavinson VKh, Egorova VV, Timofeeva NM, Malinin VV, Gordova LA, Gromova LV. Effect of Vilon and Epithalon on glucose and glycine absorption in various regions of small intestine in aged rats. Bull Exp Biol Med. 2002;133(5):494-496. doi:10.1023/a:1019878224754