How Effective Are CBD Gummies For Inflammation?

Taking CBD can have a number of benefits. It can help to reduce inflammation and oxidative stress which means the improvement of overall wellbeing. 

But how does it address inflammation in particular? And which types of inflammation? Why gummies and which gummies to take? 

Area52 is one of the recommended suppliers and while there’s more, you need to watch the labels carefully and ensure that the gummies have been tested officially by a third party lab. 

And, here are the reasons why gummies in particular, are the best way to take CBD. 

Gummies – The Best Way of Taking CBD

Taking CBD gummies is one of the most convenient ways to get your daily dose of CBD. This form of CBD supplement is also a fun and tasty way to get a CBD boost. 

You might also want to experiment with the dosage to see what works best for you.

Not Every Gummy is Same

There are four different potencies of CBD gummies available. If you are looking to increase your dosage, you should start with a low dosage, and gradually increase it to get the best effects. 

The higher your dose, the more likely you are to experience adverse side effects. The effects of CBD gummies last for about six hours, though the exact duration can vary depending on your body’s needs. 

If you are using CBD gummies as a supplement, you should also consider the ingredients in your gummies, which can affect the effectiveness of the CBD.

If you are unsure which dosage is right for you, it is best to consult a health professional. 

When to Take a CBD Gummy?

CBD gummies can be taken anytime, anywhere. They are not psychoactive, so you will not experience any euphoric effects when you take them.

For CBD gummies to work, you have to absorb the contents through your digestive system. This means that you should take them at least an hour before bedtime. You should also make sure that you store them in a cool, dry place away from sunlight. They may degrade if they are left in the sun for too long. 

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You may want to cut your gummy into two and take one in the morning and one at night.

It is important to note that while gummies are a convenient way to get your daily dose of CBD, they take longer to work out than CBD vapes, for example. It can take up to two hours for CBD gummies to start taking effect, and up to 45 minutes for the effects to kick in. 

That is not to say that you won’t get any benefits from using gummies, but you should be aware that it will take time to achieve your desired results.

You should also consider how your metabolism and body reacts to cannabinoids. If you have a sensitive stomach, you may not want to take a higher dose. If you are taking medication, you may want to avoid taking it at the same time as your CBD. 

CBD Gummies: Benefits

Aside from providing the usual benefits of CBD, these products can help you with muscle soreness and stress. Plus, they can provide a boost in energy and focus, giving you an overall better sense of wellbeing.

Rheumatoid Arthritis

RA is an autoimmune inflammatory disease that causes the immune system to attack healthy tissue. The symptoms include joint inflammation, pain, stiffness, and reduced mobility. It is common in the knees and hands, but it can affect other parts of the body, including the eyes, heart, lungs, and the joints of the fingers. Treatments include arthritis medications, physical therapy, and joint bracing.

And there’s a new take on this when we look at CBD gummies. 

Studies have found that cannabidiol (CBD), the main non-psychoactive component of the cannabis plant, is a potent anti-inflammatory agent. However, the mechanism of action is not known. 

As such, more studies are needed to determine if CBD reduces inflammation in arthritis.

One study examined the effects of CBD on TNF-activated RASF. CBD decreased the production of cytokines, which are proteins involved in inflammation. The study also investigated whether the compound affected cell viability. Using fluorescent dyes, the researchers measured intracellular calcium levels.

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The results showed that CBD decreased IL-6, IL-8, and MMP-3 levels. This reduction was enhanced by TNF pre-treatment. Additionally, CBD blocked the proliferation of antigen-specific lymphocytes. RASF are a group of cells that mediate the inflammatory response.

Another study investigated the effects of CBD on collagen-induced arthritis. CBD inhibited the formation of type II collagen and blocked the formation of collagen-induced arthritis in DBA/1 mice. The effects of CBD were mediated by a combination of enzymes and mPTP.

Oxidative Stress

CBD can also act as an antioxidant. The antioxidant system normally protects the body from stressors. However, prolonged stressors overwhelm the system, resulting in oxidative stress. CBD can decrease oxidative stress by suppressing the activity of a protein called phosphorylated p38

The suppression of p38 can decrease the activity of the NF-kB, which is responsible for the regulation of many inflammatory pathways.

Activation of endocannabinoid receptors is known to protect against the injurious effects of stressors. CBD is a cannabinoid that activates this system. 

Its effects include inhibition of chemokines, inflammation, and pain. Activating these receptors also prevents oxidative stress.

The Biomechanics of CBD

The CBD receptor is not completely understood. The mechanism remains unknown, but it appears to have an anti-inflammatory effect. 

It has been shown to reduce the production of proinflammatory cytokines such as IL-6 and IFN-g. It also suppresses TNF-g in human mononuclear cells.

Endocannabinoid System

The endocannabinoid system is composed of several receptors, including CB1 and CB2 receptors, as well as glutamate receptors (NMDA). CBD has been shown to activate these receptors and reduce inflammation.


Several studies have investigated the effects of CBD on immune cells, including macrophages. CBD has been shown to reduce inflammation and increase anti-inflammatory activity. 

These effects are believed to be mediated by PPAR-gamma, which is present in neurons that produce the enzyme APP.


Gummies come in many different flavors, allowing you to pick the one that best suits your taste. 

There are also CBD gummies available with oil, which can help your body absorb more CBD and also spur the onset of the effect but the absorption rate can vary depending on your diet and metabolism.